SNS-314

Catalog No.: A10851

Aurora inhibitor

SNS-314

SNS-314 Chemical Structure

CAS NO. 1057249-41-8

SNS-314 Mesylate is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1.

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5 mg

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10 mg

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50 mg

Regular Price: $380.00

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100 mg

Regular Price: $680.00

Special Price $544.00

10mM * 1mL in DMSO

Regular Price: $133.00

Special Price $106.40

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Biological Activity

SNS-314 Mesylate is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1.
Targets
Aurora C Aurora A Aurora B
3 nM9 nM31 nM
In vitro DMSO Warmed: 80 mg/mL (151.79 mM)
Water Insoluble
Ethanol Warmed: 1 mg/mL (1.89 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.98 mL 94.88 mL 189.75 mL
0.5 mM 3.8 mL 18.98 mL 37.95 mL
1 mM 1.9 mL 9.49 mL 18.98 mL
5 mM 0.38 mL 1.9 mL 3.8 mL

*The above data is based on the productmolecular weight 527.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10851
Actions Inhibitor
CAS No. 1057249-41-8
Formula C18H15ClN6OS2.CH4O3S
M. Wt 527.0
Purity >98%
Synonyms SNS314
SMILES CS(=O)(=O)O.C1=CC(=CC(=C1)Cl)NC(=O)NC2=NC=C(S2)CCNC3=NC=NC4=C3SC=C4
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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