SNS-314

Catalog No.: A10851

Aurora inhibitor

SNS-314

SNS-314 Chemical Structure

CAS NO. 1146618-41-8

SNS-314 Mesylate is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1.

Availability: In stock

Package Price Qty
5 mg
$70.00
10 mg
$120.00
50 mg
$380.00
100 mg
$680.00
10mM * 1mL in DMSO
$133.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

SNS-314 Mesylate is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1.
Targets
Aurora C Aurora A Aurora B
3 nM9 nM31 nM
In vitro (25°C) DMSO 105 mg/mL (199.22 mM)
Water 6 mg/mL (11.38 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.98 mL 94.88 mL 189.75 mL
0.5 mM 3.8 mL 18.98 mL 37.95 mL
1 mM 1.9 mL 9.49 mL 18.98 mL
5 mM 0.38 mL 1.9 mL 3.8 mL

*The above data is based on the productmolecular weight 527.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10851
Actions Inhibitor
M. Wt 527.0
Formula C18H15ClN6OS2.CH4O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1146618-41-8
Synonyms SNS314
SMILES CS(=O)(=O)O.C1=CC(=CC(=C1)Cl)NC(=O)NC2=NC=C(S2)CCNC3=NC=NC4=C3SC=C4

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