SR1555 hydrochloride is a selective inverse agonist of the retinoic acid receptor-related orphan nuclear receptor γ (RORγ), exhibiting an IC50 of 1 μM. This compound effectively inhibits the development and function of pro-inflammatory TH17 cells while promoting an increase in anti-inflammatory T regulatory (Treg) cells. SR1555 hydrochloride is primarily utilized in research targeting autoimmune diseases, providing insights into potential therapeutic strategies for immune modulation.
SR1555 hydrochloride is a selective inverse agonist of the retinoic acid receptor-related orphan nuclear receptor γ (RORγ), exhibiting an IC50 of 1 μM. This compound effectively inhibits the development and function of pro-inflammatory TH17 cells while promoting an increase in anti-inflammatory T regulatory (Treg) cells. SR1555 hydrochloride is primarily utilized in research targeting autoimmune diseases, providing insights into potential therapeutic strategies for immune modulation.
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