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Gli

GLI inhibitors act on glioma-associated oncogene transcription factors at the end of the Hedgehog pathway. The first family member, glioma-associated oncogene 1 (GLI1), was identified in 1987 as an amplified and highly expressed gene in a human glioma. GLI1, GLI2 and GLI3 are zinc finger proteins that bind DNA and turn Hedgehog target genes on or off. Because GLI proteins can also be activated without Smoothened, compounds acting on them probe signaling below the receptor. In a 2007 cell-based screen, GANT61 and GANT 58 reduced GLI1-driven transcription and tumor cell growth. The set also lists GLI1-IN-1 and the Smoothened antagonist PF-5274857, while the Hedgehog category covers compounds acting across the pathway.

Cat. No.

A15735

CAS No.

79498-31-0

Glaucocalyxin A

Glaucocalyxin A is an ent-kauranoid diterpene derived from Rabdosia japonica var. This compound acts as an apoptosis inducer by inhibiting the nuclear translocation of Five-zinc finger Glis 1 (GLI1), effectively modulating the PI3K/Akt signaling pathway. Its notable antitumor properties make Glaucocalyxin A a valuable reagent for research in cancer biology, particularly in studies focused on osteosarcoma.

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1 mg

$30.00

5 mg

$65.00

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Gli

Glaucocalyxin A