Search by product name, CAS, target or catalog number. Press Down Arrow to reach product suggestions, Tab to move between links, and Escape to close suggestions.
Wnt pathway inhibitors and activators modulate signaling by secreted Wnt proteins through β-catenin and its partners. Without a Wnt signal, a destruction complex built on axin phosphorylates β-catenin and marks it for proteasomal degradation. Tankyrase inhibition stabilizes axin, so XAV 939 and IWR-1-endo promote β-catenin breakdown and reduce Wnt target gene expression. LGK-974 and Wnt-C59 inhibit porcupine (PORCN), the acyltransferase that lipid-modifies Wnt proteins before their secretion. ICG-001 blocks the binding of β-catenin to the coactivator of cyclic adenosine monophosphate response element-binding protein (CREB), known as CREB-binding protein (CBP). BML-284 acts in the opposite direction, as a Wnt agonist that induces β-catenin-dependent transcription.
Neurodazine is a neurogenesis inducer that promotes the differentiation of pluripotent cells into neuronal lineages. This compound activates the Wnt and Shh signaling pathways, facilitating neural development and potentially improving neuroregeneration applications. Neurodazine is suitable for research in developmental biology, neuroscience, and regenerative medicine.
