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Swinholide A

Catalog No.: A28415
Actin Disrupter
Swinholide A is an actin disrupter that binds to actin with a dissociation constant (Kd) of approximately 50 nM, facilitating the dimerization of actin. This marine polyketide functions as a microfilament-disrupting agent, stabilizing actin dimers while severing existing actin filaments, thereby profoundly affecting the actin cytoskeleton in cells. Additionally, Swinholide A exhibits antifungal activity, making it a valuable tool for research in cellular dynamics and fungal pathogenesis.
Swinholide A 95927-67-6 Actin Disrupter
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Size Price Stock Qty
10µg
$180.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionSwinholide A is an actin disrupter that binds to actin with a dissociation constant (Kd) of approximately 50 nM, facilitating the dimerization of actin. This marine polyketide functions as a microfilament-disrupting agent, stabilizing actin dimers while severing existing actin filaments, thereby profoundly affecting the actin cytoskeleton in cells. Additionally, Swinholide A exhibits antifungal activity, making it a valuable tool for research in cellular dynamics and fungal pathogenesis.
Product Information
Catalog NumA28415
FormulaC78H132O20
Molecular Weight1389.87
CAS Number95927-67-6
SMILESC[C@H]([C@](OC(/C=C/C(C)=C/C[C@@H](C[C@@](C=CC1)([H])O[C@]1([H])C[C@@H]([C@H]([C@H](C[C@H]([C@@H]2C)O)O)C)OC)O)=O)([H])[C@H]([C@@H](C[C@@H]([C@@H]([C@H](C[C@@]3([H])O[C@@](C[C@H](C/C=C(/C=C/C(O[C@]2([H])[C@@H](C)[C@@H](O)[C@@H](C)CC[C@H](O[C@H]4C)C[C@@H](C4)OC)=O)C)O)([H])C=CC3)OC)C)O)O)C)[C@@H](O)[C@@H](C)CC[C@H](O[C@H]5C)C[C@@H](C5)OC
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Microbiology > Antifection > Fungal