T-22

Catalog No.: A50675
Anti-HIV Synthetic Peptides
T-22 is an anti-HIV synthetic peptide that specifically targets viral entry by disrupting the fusion process of the virus with host cells. Demonstrating potent antiviral activity with an EC50 of 0.008 μg/mL, T-22 exhibits a CC50 of 54 μg/mL, indicating its relative safety for cellular application. In addition to its antiviral properties, T-22 has been shown to enhance plant growth, photosynthesis, total chlorophyll content, and gas exchange in tomatoes, as well as provide resistance against Cucumber Mosaic Virus (CMV). This multifunctional peptide serves as a valuable tool in both virology and agricultural research.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionT-22 is an anti-HIV synthetic peptide that specifically targets viral entry by disrupting the fusion process of the virus with host cells. Demonstrating potent antiviral activity with an EC50 of 0.008 μg/mL, T-22 exhibits a CC50 of 54 μg/mL, indicating its relative safety for cellular application. In addition to its antiviral properties, T-22 has been shown to enhance plant growth, photosynthesis, total chlorophyll content, and gas exchange in tomatoes, as well as provide resistance against Cucumber Mosaic Virus (CMV). This multifunctional peptide serves as a valuable tool in both virology and agricultural research.
Product Information
Catalog NumA50675
FormulaC109H164N38O22S4
Molecular Weight2486.97
CAS Number147658-54-6
SequenceArg-Arg-Trp-Cys-Tyr-Arg-Lys-Cys-Tyr-Lys-Gly-Tyr-Cys-Tyr-Arg-Lys-Cys-Arg-NH2 (Disulfide bridge: Cys4-Cys17,Cys8-Cys13)
Sequence shorteningRRWCYRKCYKGYCYRKCR-NH2 (Disulfide bridge: Cys4-Cys17,Cys8-Cys13)
SMILESC([C@@H](C(N[C@@H]1C(=O)N[C@@H](CC2=CC=C(O)C=C2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@]3(C(=O)N[C@@H](CC4=CC=C(O)C=C4)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CC5=CC=C(O)C=C5)C(=O)N[C@@](CSSC3)(C(=O)N[C@@H](CC6=CC=C(O)C=C6)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(N[C@@H](CCCNC(=N)N)C(N)=O)=O)CSSC1)[H])[H])=O)NC([C@@H](NC([C@H](CCCNC(=N)N)N)=O)CCCNC(=N)N)=O)C=7C=8C(NC7)=CC=CC8
Synonyms[Tyr5,12,Lys7]-Polyphemusin II
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