Tamoxifen-d3 is a deuterium-labeled derivative of Tamoxifen, a selective estrogen receptor modulator (SERM) that primarily functions by inhibiting estrogen action in breast tissue while potentially activating it in other tissues such as bone, liver, and uterus. This compound serves as a powerful Hsp90 activator, enhancing ATPase activity, and exhibits inhibition of EBOV Zaire and Marburg viruses with IC50 values of 0.1 μM and 1.8 μM, respectively. Tamoxifen-d3 is used in various research applications including studies on autophagy, apoptosis induction, and gene knockout in CreER(T2) transgenic models.
Tamoxifen-d3 is a deuterium-labeled derivative of Tamoxifen, a selective estrogen receptor modulator (SERM) that primarily functions by inhibiting estrogen action in breast tissue while potentially activating it in other tissues such as bone, liver, and uterus. This compound serves as a powerful Hsp90 activator, enhancing ATPase activity, and exhibits inhibition of EBOV Zaire and Marburg viruses with IC50 values of 0.1 μM and 1.8 μM, respectively. Tamoxifen-d3 is used in various research applications including studies on autophagy, apoptosis induction, and gene knockout in CreER(T2) transgenic models.
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