Fig. 1 · Structure
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TASIN-1 hydrochloride
APC(TR) Inhibitor
TASIN-1 hydrochloride is a selective inhibitor of truncated APC (adenomatous polyposis coli) that demonstrates cytotoxic effects through the suppression of cholesterol biosynthesis. This reagent specifically targets colorectal cancer cells harboring APC truncated mutations, while exhibiting minimal toxicity to wild-type APC cells. TASIN-1 hydrochloride induces endoplasmic reticulum (ER) stress, elevates reactive oxygen species (ROS), and triggers JNK-mediated apoptosis, while concurrently inhibiting Akt survival signaling. It serves as a valuable tool for research focused on the prevention and intervention of APC mutant colorectal cancer.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1678515-13-3 |
| Applications | APC(TR) Inhibitor |
| Formula | C18H29ClN2O3S |
| Molecular Weight | 388.95 |
| SMILES | CC1CCN(C2CCN(S(=O)(C3=CC=C(OC)C=C3)=O)CC2)CC1.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.