Fig. 1 · Structure
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TASIN-1
APC(TR) Inhibitor
TASIN-1 is a selective inhibitor of truncated adenomatous polyposis coli gene (APC) that induces cytotoxic effects by disrupting cholesterol biosynthesis. This compound specifically targets colorectal cancer (CRC) cells harboring APC truncated mutations, demonstrating minimal toxicity to wild-type APC cells. By inhibiting Emopamil binding protein (EBP), TASIN-1 triggers endoplasmic reticulum (ER) stress, generates reactive oxygen species (ROS), and activates JNK-mediated apoptosis while suppressing Akt survival signaling. TASIN-1 is relevant for research focused on APC mutant colorectal cancer intervention and prevention.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 792927-06-1 |
| Applications | APC(TR) Inhibitor |
| Formula | C18H28N2O3S |
| Molecular Weight | 352.49 |
| SMILES | CC1CCN(C2CCN(S(=O)(C3=CC=C(OC)C=C3)=O)CC2)CC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.