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TAT-PiET

Catalog No.: A40413
BRD4 Inhibitor
TAT-PiET is a cell-penetrating peptide that specifically inhibits the extra-terminal (ET) domain of bromodomain-containing protein 4 (BRD4). This reagent demonstrates significant biological activity by reducing levels of both BRD4 and JMJD6, thereby effectively inhibiting cell proliferation. TAT-PiET exhibits resilience against endocrine resistance in estrogen receptor alpha (ERα)-positive breast cancer cells, making it a valuable tool for cancer research, particularly within the context of breast cancer studies.
TAT-PiET 3036046-03-1 BRD4 Inhibitor
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTAT-PiET is a cell-penetrating peptide that specifically inhibits the extra-terminal (ET) domain of bromodomain-containing protein 4 (BRD4). This reagent demonstrates significant biological activity by reducing levels of both BRD4 and JMJD6, thereby effectively inhibiting cell proliferation. TAT-PiET exhibits resilience against endocrine resistance in estrogen receptor alpha (ERα)-positive breast cancer cells, making it a valuable tool for cancer research, particularly within the context of breast cancer studies.
Product Information
Catalog NumA40413
FormulaC110H192N48O27S
Molecular Weight2651.07
CAS Number3036046-03-1
SequenceTyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Asn-Gln-Lys-Phe-Lys-Cys-Gly-Glu
Sequence shorteningYGRKKRRQRRRRNQKFKCGE
SMILES[C@@H](CC1=CC=CC=C1)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@H](CC2=CC=C(O)C=C2)N)=O)=O)CCCNC(=N)N)=O)CCCCN)=O)CCCCN)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CC(N)=O)=O)CCC(N)=O)=O)CCCCN)=O)C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CCC(O)=O)C(O)=O)=O)=O)CS)=O)CCCCN)=O
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