We use analytics and advertising cookies, which you can accept or reject; see our privacy policy.

Current choice:

Fig. 1 · Structure
Cat. No.
A17271
CAS No.
14605-22-2
Formula
C26H45NO6S
Mol. Weight
499.7

Documents & Downloads

Tauroursodeoxycholate

Cat. No. A17271 CAS 14605-22-2

ER stress inhibitor

Tauroursodeoxycholate (TUDCA; UR 906; Taurolite) is an endoplasmic reticulum (ER) stress inhibitor.

In Stock

Notify me when the price drops

For laboratory research use only. We do not sell to patients.

Free Aliquoting for Your Order

Tell us your preferred amount per vial. We’ll confirm the options.

Biological Activity

Target & Activity

Target Activity Value
Human Endogenous Metabolite  

Cellular Effect

Cell Line Activity Value Description Reference
CHO EC50 30 μM Agonist activity at human TGR5 expressed in CHO cells by luciferase assay [PMID: 18307294]
HEK293 IC50 10.3 μM Inhibition of human ATX expressed in HEK293 Flp-In cells assessed as decrease in choline release from LPC measured every 30 secs for 90 mins by HVA based fluorescence assay [PMID: 28165241]
HEK293 EC50 105.15 μM Agonist activity at human TGR5 Y89A mutant expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay [PMID: 26435512]
HEK293 EC50 50.5 μM Agonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay [PMID: 26435512]
HET-1A CC50 1002 μM Cytotoxicity against human HET-1A cells assessed as cell viability after 24 hrs by MTT assay [PMID: 20713311]

Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 14605-22-2
Applications ER stress inhibitor
Formula C26H45NO6S
Molecular Weight 499.7
Synonyms TUDCA; UR 906; Taurolite
SMILES
C[C@H](CCC(NCCS(=O)(O)=O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO 84 mg/mL (168.09 mM)
Water 26 mg/mL (52.03 mM)
Ethanol 84 mg/mL (168.09 mM)

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Added to your cart

View Cart Checkout
Loading...