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TBAJ-876

Mycobacterium Tuberculosis Inhibitor

TBAJ-876 is an orally bioavailable diarylquinoline that inhibits Mycobacterium tuberculosis by targeting the c and ε subunits of its F-ATP synthase. It demonstrates bactericidal activity against replicating Mycobacterium tuberculosis, including strains with the Rv0678 mutation, and is metabolized in vivo to form the active metabolite TBAJ-876-M3, which has reduced lipophilicity. TBAJ-876 is well tolerated in animal models, significantly decreasing colony-forming units of Mycobacterium tuberculosis in the lungs and demonstrating efficacy against Mycobacterium abscessus. Its compatibility with common antibiotics makes it valuable for research on tuberculosis and related pulmonary infections.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2332841-25-3
Applications	Mycobacterium Tuberculosis Inhibitor
Formula	C₃₁H₃₇BrN₄O₇
Molecular Weight	657.55
SMILES	COC1=NC(OC)=C(OC)C([C@H](C2=CC(C=C(Br)C=C3)=C3N=C2OC)[C@@](C4=CC(OC)=NC(OC)=C4)(O)CCN(C)C)=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.