TC-G 1005 is a selective agonist of the Takeda G protein-coupled receptor 5 (TGR5), demonstrating potent activity with EC50 values of 0.72 nM for human TGR5 and 6.2 nM for mouse TGR5. This compound has been shown to effectively reduce glucose levels in vivo, making it a valuable tool for researching metabolic disorders and the role of TGR5 in glucose homeostasis. Its oral bioactivity supports its application in various pharmacological studies related to energy metabolism and diabetic therapies.
TC-G 1005 is a selective agonist of the Takeda G protein-coupled receptor 5 (TGR5), demonstrating potent activity with EC50 values of 0.72 nM for human TGR5 and 6.2 nM for mouse TGR5. This compound has been shown to effectively reduce glucose levels in vivo, making it a valuable tool for researching metabolic disorders and the role of TGR5 in glucose homeostasis. Its oral bioactivity supports its application in various pharmacological studies related to energy metabolism and diabetic therapies.
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