Fig. 1 · Structure
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TCMDC-135051 hydrochloride
PfCLK3 Inhibitor
TCMDC-135051 hydrochloride is a potent and selective inhibitor of the protein kinase PfCLK3, exhibiting low off-target toxicity. This compound effectively hinders the transition of Plasmodium falciparum from trophozoite to schizont stages, disrupts transcriptional processes, and reduces transmission to mosquito vectors. With an antiparasitic efficacy characterized by an EC50 value of 320 nM, TCMDC-135051 hydrochloride is a valuable tool for malaria research and potential therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2705545-47-5 |
| Applications | PfCLK3 Inhibitor |
| Formula | C29H34ClN3O3 |
| Molecular Weight | 508.05 |
| SMILES | O=C(O)C1=CC=C(C2=C3C(NC(C4=C(OC)C=CC(CN(CC)CC)=C4)=C3)=NC=C2)C=C1C(C)C.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.