Fig. 1 · Structure
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TCMDC-135051
PfCLK3 Inhibitor
TCMDC-135051 is a potent and selective inhibitor of the protein kinase PfCLK3, specifically targeting Plasmodium falciparum. This compound effectively prevents the transition from trophozoite to schizont, disrupts transcription processes, and reduces transmission to mosquito vectors. TCMDC-135051 demonstrates significant antiparasitic activity with an EC50 of 320 nM, making it a valuable tool for research in malaria treatment and transmission control.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2413716-15-9 |
| Applications | PfCLK3 Inhibitor |
| Formula | C29H33N3O3 |
| Molecular Weight | 471.59 |
| SMILES | O=C(O)C1=CC=C(C2=C3C(NC(C4=C(OC)C=CC(CN(CC)CC)=C4)=C3)=NC=C2)C=C1C(C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.