Fig. 1 · Structure
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Telaglenastat hydrochloride
Glutaminase 1 Inhibitor
Telaglenastat hydrochloride is a selective, reversible inhibitor of glutaminase 1 (GLS1), exhibiting oral bioavailability. This compound selectively targets GLS1 splice variants KGA and GAC, demonstrating IC50 values of 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain tissues, respectively. Telaglenastat hydrochloride is shown to induce autophagy and possesses significant antitumor activity, making it valuable for research in cancer metabolism and therapeutic applications targeting glutaminase activity.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1874231-60-3 |
| Applications | Glutaminase 1 Inhibitor |
| Formula | C26H25ClF3N7O3S |
| Molecular Weight | 608.04 |
| Synonyms | CB-839 hydrochloride |
| SMILES | [H]Cl.O=C(NC1=NN=C(CCCCC2=NN=C(NC(CC3=CC=CC(OC(F)(F)F)=C3)=O)C=C2)S1)CC4=NC=CC=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.