Fig. 1 · Structure
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Tenapanor hydrochloride
NHE3 Inhibitor
Tenapanor hydrochloride is a potent inhibitor of the sodium/hydrogen exchanger isoform 3 (NHE3). This compound effectively reduces intestinal phosphate absorption primarily by decreasing passive paracellular phosphate flux. Tenapanor hydrochloride is valuable for research focused on hyperphosphatemia and related metabolic disorders. It serves as a useful tool in evaluating the mechanisms underlying phosphate homeostasis in physiological and pathological conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1234365-97-9 |
| Applications | NHE3 Inhibitor |
| Formula | C50H68Cl6N8O10S2 |
| Molecular Weight | 1217.97 |
| Synonyms | AZD1722 hydrochloride; RDX5791 hydrochloride |
| SMILES | O=S(C1=CC=CC([C@@H]2CN(C)CC3=C2C=C(Cl)C=C3Cl)=C1)(NCCOCCOCCNC(NCCCCNC(NCCOCCOCCNS(=O)(C4=CC=CC([C@@H]5CN(C)CC6=C5C=C(Cl)C=C6Cl)=C4)=O)=O)=O)=O.[H]Cl.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.