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TGF-β/Smad Inhibitors

TGF-β/Smad inhibitors block transforming growth factor beta (TGF-β) signaling at its receptor kinases or Smad proteins. TGF-β binds a type II receptor kinase, which then phosphorylates the type I receptor, activin receptor-like kinase 5 (ALK5). The activated type I receptor phosphorylates Smad2 and Smad3, which join Smad4 and move into the nucleus to regulate transcription. SB 431542 and A 83-01 inhibit ALK5 together with the related receptors ALK4 and ALK7. RepSox and galunisertib also target the TGF-β type I receptor, while SIS3 blocks Smad3 downstream. LDN193189 instead inhibits ALK2 and ALK3, type I receptors for bone morphogenetic proteins.

Cat. No.

A84872

CAS No.

1169766-01-1

Ramatercept

Synonyms: ACE-031

Ramatercept is a soluble activin receptor 2 (ACVR2) antagonist that functions by inhibiting the signaling pathway associated with muscle growth suppression. It has demonstrated potential in the treatment of muscle atrophy by modulating myostatin activity, making it a valuable tool for research in muscle biology and related therapeutic applications. Researchers may utilize Ramatercept to explore mechanisms of muscle wasting and to develop strategies for promoting muscle growth.

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1 mg

$320.00

5 mg

$920.00

All 3 sizes
Cat. No.

A84895

CAS No.

1060469-90-0

NUCC-555

NUCC-555 is an activin antagonist that targets the Activin A binding pocket, specifically interacting with critical residues such as Trp25, Trp28, Phe55, Tyr93, Lys103, and Asn107. This compound effectively inhibits Activin A-mediated activation of hepatic stellate cells (HSCs), promoting liver regeneration and slowing the progression of fibrosis in chronic liver disease models. Additionally, NUCC-555 suppresses ovarian cell proliferation driven by Activin A and reduces follicle-stimulating hormone (FSH) levels in ovariectomized mouse models, making it a valuable tool for research in liver and reproductive health.

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