Fig. 1 · Structure
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Theaflavin 3,3'-digallate
Virus Protease Inhibitor
Theaflavin 3,3'-digallate is a potent Zika virus protease inhibitor, exhibiting an IC50 value of 2.3 μM. It effectively binds to the ZIKV protease with a dissociation constant (Kd) of 8.86 μM, inhibiting viral replication. Additionally, it demonstrates inhibitory activity against other viral proteases such as gp41 and NS2B-3, with proven antiviral efficacy against HSV and HIV-1. This compound, commonly found in black tea, also possesses significant antitumor properties, making it valuable for diverse biological research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 30462-35-2 |
| Applications | Virus Protease Inhibitor |
| Formula | C43H32O20 |
| Molecular Weight | 868.70 |
| Synonyms | TF-3; ZP10 |
| SMILES | O=C(C1=CC(O)=C(C(O)=C1)O)O[C@H]2[C@H](OC3=CC(O)=CC(O)=C3C2)C4=C5C(C(C(O)=CC([C@@H]6[C@@H](CC7=C(O)C=C(O)C=C7O6)OC(C8=CC(O)=C(C(O)=C8)O)=O)=C5)=O)=C(C(O)=C4)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.