Thiocolchicine-d3 is a deuterium-labeled derivative of Thiocolchicine, which acts as a potent inhibitor of tubulin polymerization. With an IC50 of 2.5 μM, it competitively binds to tubulin, exhibiting a Ki of 0.7 μM. This compound is known to induce apoptosis in cells and can serve as a cytotoxic agent in antibody-drug conjugate (ADC) applications, making it valuable for cancer research and therapeutic development.
Thiocolchicine-d3 is a deuterium-labeled derivative of Thiocolchicine, which acts as a potent inhibitor of tubulin polymerization. With an IC50 of 2.5 μM, it competitively binds to tubulin, exhibiting a Ki of 0.7 μM. This compound is known to induce apoptosis in cells and can serve as a cytotoxic agent in antibody-drug conjugate (ADC) applications, making it valuable for cancer research and therapeutic development.
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