Fig. 1 · Structure
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Thiophene-2
Pks13 Inhibitor
Thiophene-2 is a selective inhibitor of polyketide synthase 13 (Pks13), targeting mycolic acid biosynthesis. This compound effectively induces cell death in mycobacteria, demonstrating potent anti-tuberculosis activity with a minimum inhibitory concentration (MIC) of 1 μM against Mycobacterium tuberculosis. Thiophene-2 serves as a valuable tool for research in tuberculosis treatment and mycobacterial metabolism studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 420089-51-6 |
| Applications | Pks13 Inhibitor |
| Formula | C18H14F5NO3S |
| Molecular Weight | 419.37 |
| SMILES | O=C(OC)C1=C(SC2=C1CCCCC2)NC(C3=C(C(F)=C(C(F)=C3F)F)F)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.