Fig. 1 · Structure
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ThrRS-IN-2
ThrRS Inhibitor
ThrRS-IN-2 is a potent inhibitor of threonyl-tRNA synthetase (ThrRS), exhibiting an IC50 value of 56.5 ± 3.5 μM. This compound can be utilized to investigate the role of ThrRS in protein synthesis and its potential implications in diseases linked to tRNA synthetase dysfunction. As a valuable tool for biochemical research, ThrRS-IN-2 aids in understanding the mechanisms of tRNA synthesis and offers insights for therapeutic development targeting protein translation pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 468750-19-8 |
| Applications | ThrRS Inhibitor |
| Formula | C16H10Br2N4O3S |
| Molecular Weight | 498.15 |
| SMILES | OC1=C(/C=N/NC2=NC(C3=CC=C([N+]([O-])=O)C=C3)=CS2)C=C(Br)C=C1Br |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.