Tiagabine-d6 is a deuterium-labeled derivative of the potent GABA reuptake inhibitor, Tiagabine. This compound selectively inhibits GABA reuptake, exhibiting IC50 values of 67 nM, 446 nM, and 182 nM in synaptosomes, neurons, and glial cells, respectively. Tiagabine-d6 is primarily utilized in research applications requiring stable isotope labeling, facilitating studies in pharmacokinetics and metabolism of GABAergic drugs.
Tiagabine-d6 is a deuterium-labeled derivative of the potent GABA reuptake inhibitor, Tiagabine. This compound selectively inhibits GABA reuptake, exhibiting IC50 values of 67 nM, 446 nM, and 182 nM in synaptosomes, neurons, and glial cells, respectively. Tiagabine-d6 is primarily utilized in research applications requiring stable isotope labeling, facilitating studies in pharmacokinetics and metabolism of GABAergic drugs.
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