Fig. 1 · Structure
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Tirofiban
Gp IIb/IIIa Receptor Antagonist
Tirofiban is a selective and reversible antagonist of the Gp IIb/IIIa receptor, primarily functioning to inhibit fibrinogen binding. This compound exhibits significant antithrombotic activity, making it valuable in studies focused on platelet aggregation and thrombus formation. Additionally, Tirofiban has been shown to promote endothelial cell proliferation and migration through increased production of vascular endothelial growth factor (VEGF). Its capabilities extend to reducing myocardial no-reflow and ischemia-reperfusion injury by improving microvascular structure and endothelial function in ischemic tissues.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 144494-65-5 |
| Applications | Gp IIb/IIIa Receptor Antagonist |
| Formula | C22H36N2O5S |
| Molecular Weight | 440.60 |
| Synonyms | L700462; MK383 |
| SMILES | O=S(N[C@H](C(O)=O)CC1=CC=C(OCCCCC2CCNCC2)C=C1)(CCCC)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.