TLR7 Agonist 22 selectively targets Toll-like receptor 7 (TLR7) with an IC50 of 25.86 μM. This compound effectively inhibits the secretion of HBsAg in cells while robustly activating TLR7, resulting in the induction of cytokines such as IL-12, TNF-α, and IFN-α in human peripheral blood mononuclear cells (PBMCs). TLR7 Agonist 22 holds potential for research focused on the development of novel immunomodulatory agents for hepatitis B virus (HBV) therapy.
TLR7 Agonist 22 selectively targets Toll-like receptor 7 (TLR7) with an IC50 of 25.86 μM. This compound effectively inhibits the secretion of HBsAg in cells while robustly activating TLR7, resulting in the induction of cytokines such as IL-12, TNF-α, and IFN-α in human peripheral blood mononuclear cells (PBMCs). TLR7 Agonist 22 holds potential for research focused on the development of novel immunomodulatory agents for hepatitis B virus (HBV) therapy.
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