TLR7 antagonist-1 is a selective antagonist of Toll-like receptor 7 (TLR7), exhibiting an IC50 value of 0.3 nM. It binds specifically to TLR7, inhibiting its activation and subsequently downregulating the c-Rel signaling pathway. This compound effectively reduces the mRNA levels of pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α. TLR7 antagonist-1 is particularly relevant for research focused on psoriasis, demonstrating efficacy in alleviating Imiquimod-induced psoriasis-like skin lesions.
TLR7 antagonist-1 is a selective antagonist of Toll-like receptor 7 (TLR7), exhibiting an IC50 value of 0.3 nM. It binds specifically to TLR7, inhibiting its activation and subsequently downregulating the c-Rel signaling pathway. This compound effectively reduces the mRNA levels of pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α. TLR7 antagonist-1 is particularly relevant for research focused on psoriasis, demonstrating efficacy in alleviating Imiquimod-induced psoriasis-like skin lesions.
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