Tolfenamic acid-13C6 is a stable isotope-labeled derivative of Tolfenamic acid, a non-steroidal anti-inflammatory and anti-cancer agent. It selectively inhibits COX-2 with an IC50 of 13.49 μM in LPS-treated canine DH82 monocyte/macrophage cells, while exhibiting no inhibitory effect on COX-1. This reagent is valuable for studying COX-2-related pathways and assessing the pharmacokinetics and metabolism of Tolfenamic acid in various biological contexts.
Tolfenamic acid-13C6 is a stable isotope-labeled derivative of Tolfenamic acid, a non-steroidal anti-inflammatory and anti-cancer agent. It selectively inhibits COX-2 with an IC50 of 13.49 μM in LPS-treated canine DH82 monocyte/macrophage cells, while exhibiting no inhibitory effect on COX-1. This reagent is valuable for studying COX-2-related pathways and assessing the pharmacokinetics and metabolism of Tolfenamic acid in various biological contexts.
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