Fig. 1 · Structure
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TP0586532
Non-Hydroxamate LpxC Inhibitor
TP0586532 is a non-hydroxamate inhibitor of LpxC, exhibiting an IC50 of 0.101 μM. This compound demonstrates potent activity against Klebsiella pneumoniae, including resistant strains, while presenting a low cardiovascular risk profile. Additionally, TP0586532 serves as a click chemistry reagent, featuring an alkyne group that allows for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, facilitating various biochemical applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2427584-96-9 |
| Applications | Non-Hydroxamate LpxC Inhibitor |
| Formula | C26H28N4O4 |
| Molecular Weight | 460.52 |
| SMILES | C[C@H](O)C1=NC=CN1CC2=NOC(C(C=C3)=CC=C3C#C[C@H]4[C@@]5([H])[C@]4([H])CN(C5)CCCC(O)=O)=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.