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ATPase inhibitors and activators target enzymes that use adenosine triphosphate (ATP) to pump ions or drive motors. The category spans several unrelated enzyme families, so compounds are listed by the ATPase they act on. Sodium-potassium ATPase (Na+/K+-ATPase), described by Skou in 1957, maintains ion gradients across the plasma membrane and is inhibited by ouabain. Vacuolar-type proton ATPases acidify lysosomes and endosomes and are blocked by bafilomycin A1. Omeprazole and esomeprazole magnesium inhibit the H+/K+-ATPase that secretes acid from gastric parietal cells. Oligomycin A inhibits mitochondrial ATP synthase, and omecamtiv mecarbil activates cardiac myosin ATPase.
Synonyms: Aldadiene; BRN 0046602; Luvion; NSC 261713; NSC 261713Phanurane
Canrenone is a metabolite of spironolactone, Na/K ATPase partial agonist and aldosterone and androgen receptor antagonist used as a diuretic.
