- Cat. No.
- A21685
Bz 423
Synonyms: BZ48
Bz-423 is an F1F0-ATPase modulator. It acts by selectively killing autoimmune lymphocytes.
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ATPase inhibitors and activators target enzymes that use adenosine triphosphate (ATP) to pump ions or drive motors. The category spans several unrelated enzyme families, so compounds are listed by the ATPase they act on. Sodium-potassium ATPase (Na+/K+-ATPase), described by Skou in 1957, maintains ion gradients across the plasma membrane and is inhibited by ouabain. Vacuolar-type proton ATPases acidify lysosomes and endosomes and are blocked by bafilomycin A1. Omeprazole and esomeprazole magnesium inhibit the H+/K+-ATPase that secretes acid from gastric parietal cells. Oligomycin A inhibits mitochondrial ATP synthase, and omecamtiv mecarbil activates cardiac myosin ATPase.
Synonyms: BZ48
Bz-423 is an F1F0-ATPase modulator. It acts by selectively killing autoimmune lymphocytes.