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ATPase

ATPase inhibitors and activators target enzymes that use adenosine triphosphate (ATP) to pump ions or drive motors. The category spans several unrelated enzyme families, so compounds are listed by the ATPase they act on. Sodium-potassium ATPase (Na+/K+-ATPase), described by Skou in 1957, maintains ion gradients across the plasma membrane and is inhibited by ouabain. Vacuolar-type proton ATPases acidify lysosomes and endosomes and are blocked by bafilomycin A1. Omeprazole and esomeprazole magnesium inhibit the H+/K+-ATPase that secretes acid from gastric parietal cells. Oligomycin A inhibits mitochondrial ATP synthase, and omecamtiv mecarbil activates cardiac myosin ATPase.

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  • RyR2 stabilizer-1
    Cat. No.
    A66414
    CAS No.
    3012675-16-7

    RyR2 stabilizer-1

    RyR2 stabilizer-1 is a potent stabilizer of the ryanodine receptor 2 (RyR2) and an activator of the sarco/endoplasmic reticulum Ca2+ ATPase 2a (SERCA2a), exhibiting EC50 values of 2.7 μM for RyR2 and 383 nM for SERCA2a. This compound effectively inhibits calcium leakage from the sarcoplasmic reticulum through RyR2 while enhancing the reuptake of calcium by SERCA2a. As a result, RyR2 stabilizer-1 shows promise in preventing cardiac arrhythmias by maintaining calcium homeostasis in cardiac cells.

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