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Gap junction protein tools act on connexin channels that link the cytoplasm of adjacent cells. A gap junction channel forms when two hemichannels, called connexons, dock across the narrow gap between adjacent plasma membranes. Each connexon is a ring of six connexin subunits, and the pore passes ions and small metabolites. Gap junctions couple cardiac myocytes, neurons, astrocytes and many epithelial cells. Gap 26 and Gap 27 are peptides matching extracellular loop sequences of connexin 43 (Cx43) that block channels and hemichannels. Rotigaptide and its dipeptide analog GAP-134 increase Cx43-mediated coupling, and tonabersat is a gap junction modulator. 10Panx is a mimetic peptide inhibitor of pannexin 1, a related large-pore channel.
Gap 26 is a connexin mimetic peptide, corresponding to residues 63-75 of connexin 43, which is a gap junction blocker.
Gap 27 is a peptide derived from connexin 43 that is a selective gap junction blocker.
