Tariquidar (XR9576)

Catalog No.: A11584

P-gp inhibitor

Tariquidar (XR9576)

Tariquidar (XR9576) Chemical Structure

CAS NO. 206873-63-4

Tariquidar (XR9576) is a P-glycoprotein drug efflux pump inhibitor.

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10 mg

Regular Price: $80.00

Special Price $64.00

25 mg

Regular Price: $160.00

Special Price $128.00

50 mg

Regular Price: $260.00

Special Price $208.00

100 mg

Regular Price: $480.00

Special Price $384.00

10mM * 1mL in DMSO

Regular Price: $124.00

Special Price $99.20

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Sugisawa N, .et al. Novel Potent ABCB1 Modulator, Phenethylisoquinoline Alkaloid, Reverses Multidrug Resistance in Cancer Cell, Mol Pharm, 2018, Sep 4;15(9):4021-4030 PMID: 30052463
  • Samy A. F. Morad, .et al. Role of P-glycoprotein inhibitors in ceramide-based therapeutics for treatment of cancer, Biochem Pharmacol, 2017, Apr 15; 130: 21-33 PMID: 28189725
  • Debora Petroni, .et al. Synthesis and In Vivo Imaging of N-(3-[11C]Methoxybenzyl)-2-(3-Methoxyphenyl)ethylaniline as a Potential Targeting Agent for P-glycoprotein, Mol Imaging Biol, 2016, Dec;18(6):916-923 PMID: 27234445

Biological Activity

Tariquidar (XR9576) is a P-glycoprotein drug efflux pump inhibitor.
Targets
P-gp (CHrB30 cells)
5.1 nM(Kd)
In vitro DMSO 48 mg/mL (74.22 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.46 mL 77.31 mL 154.62 mL
0.5 mM 3.09 mL 15.46 mL 30.92 mL
1 mM 1.55 mL 7.73 mL 15.46 mL
5 mM 0.31 mL 1.55 mL 3.09 mL

*The above data is based on the productmolecular weight 646.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11584
Actions Inhibitor
CAS No. 206873-63-4
Formula C38H38N4O6
M. Wt 646.73
Purity >98%
Synonyms XR 9576??XR9576??D06008
SMILES COC1=C(C=C2CN(CCC2=C1)CCC3=CC=C(C=C3)NC(=O)C4=CC(=C(C=C4NC(=O)C5=CC6=CC=CC=C6N=C5)OC)OC)OC
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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