Tariquidar (XR9576)

Catalog No.: A11584

P-gp inhibitor

Tariquidar (XR9576)

Tariquidar (XR9576) Chemical Structure

CAS NO. 206873-63-4

Tariquidar (XR9576) is a P-glycoprotein drug efflux pump inhibitor.

Availability: In stock

Package Price Qty
10 mg
$80.00
25 mg
$160.00
50 mg
$260.00
100 mg
$480.00
10mM * 1mL in DMSO
$124.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Sugisawa N, .et al. Novel Potent ABCB1 Modulator, Phenethylisoquinoline Alkaloid, Reverses Multidrug Resistance in Cancer Cell, Mol Pharm, 2018, Sep 4;15(9):4021-4030 PMID: 30052463
  • Samy A. F. Morad, .et al. Role of P-glycoprotein inhibitors in ceramide-based therapeutics for treatment of cancer, Biochem Pharmacol, 2017, Apr 15; 130: 21-33 PMID: 28189725
  • Debora Petroni, .et al. Synthesis and In Vivo Imaging of N-(3-[11C]Methoxybenzyl)-2-(3-Methoxyphenyl)ethylaniline as a Potential Targeting Agent for P-glycoprotein, Mol Imaging Biol, 2016, Dec;18(6):916-923 PMID: 27234445

Biological Activity

Tariquidar (XR9576) is a P-glycoprotein drug efflux pump inhibitor.
Targets
P-gp (CHrB30 cells)
5.1 nM(Kd)
In vitro (25°C) DMSO 52 mg/mL (80.4 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.46 mL 77.31 mL 154.62 mL
0.5 mM 3.09 mL 15.46 mL 30.92 mL
1 mM 1.55 mL 7.73 mL 15.46 mL
5 mM 0.31 mL 1.55 mL 3.09 mL

*The above data is based on the productmolecular weight 646.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11584
Actions Inhibitor
M. Wt 646.73
Formula C38H38N4O6
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 206873-63-4
Synonyms XR 9576??XR9576??D06008
SMILES COC1=C(C=C2CN(CCC2=C1)CCC3=CC=C(C=C3)NC(=O)C4=CC(=C(C=C4NC(=O)C5=CC6=CC=CC=C6N=C5)OC)OC)OC

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