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Potassium Channels

Potassium channel blockers and openers target the largest and most diverse family of ion channels. Potassium (K+) channels set the resting membrane potential and shape action potentials, hormone secretion and immune cell activation. The 1998 crystal structure of the potassium channel from Streptomyces lividans (KcsA) showed how a narrow selectivity filter passes K+ ions but excludes sodium ions. Major families include voltage-gated (Kv), calcium-activated (KCa) and inward-rectifier (Kir) channels. Adenosine triphosphate (ATP)-sensitive K+ (KATP) channels pair a Kir6.2 pore with a sulfonylurea receptor (SUR) subunit. The sulfonylureas glimepiride and glyburide close KATP channels, whereas minoxidil is studied as a channel opener. TRAM-34 blocks the intermediate-conductance KCa3.1 channel, and PAP-1 blocks Kv1.3, two channels studied in T lymphocyte activation.

1 Item

  • Desethylamiodarone hydrochloride
    Cat. No.
    A39497
    CAS No.
    96027-74-6

    Desethylamiodarone hydrochloride

    Synonyms: N-desethylamiodarone hydrochloride; LB 33020 hydrochloride

    Desethylamiodarone hydrochloride is a significant active metabolite of Amiodarone, primarily functioning as an autophagy inducer. It is produced through the action of CYP3A isoenzymes and plays a critical role in cellular processes affecting autophagy. This compound is utilized in research applications focusing on cardiovascular pharmacology and cellular stress responses, due to its influence on potassium channels and potential therapeutic implications in arrhythmias.

    In stock View Details
    5 mg
    $125.00
    10 mg
    $210.00
    All 5 sizes

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