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Calcium Channels

Calcium channel blockers act on voltage-gated channels that let calcium ions enter excitable cells. Voltage-gated calcium (CaV) channels couple membrane depolarization to muscle contraction, neurotransmitter release and gene expression. Channel types are classed as L-, N-, P/Q-, R- and T-type according to their electrophysiological and pharmacological properties. The pore-forming α1 subunit of the L-type channel was first sequenced in 1987 as the skeletal muscle receptor for calcium channel blockers. Dihydropyridines in this category include isradipine, nimodipine and amlodipine besylate, which bind L-type channels. The benzothiazepine diltiazem HCl acts on the same channel type at a distinct binding site. BAPTA/AM, the cell-permeant ester of a calcium chelator, is listed for buffering intracellular calcium rather than for blocking channels.

3 Items

  • PDDHV
    Cat. No.
    A66399
    CAS No.
    179469-40-0

    PDDHV

    PDDHV is a potent calcium absorption inducer that stimulates the vanillic acid receptor VR1, leading to increased influx of 45Ca2+. It effectively promotes 45Ca2+ uptake in rat dorsal root ganglion neurons with an EC50 of 70 nM and elicits calcium mobilization in VR1-transfected CHO cells with an EC50 of 125 nM. Additionally, PDDHV inhibits [3H]-resiniferatoxin binding to rat dorsal root ganglion membranes, showcasing its utility in calcium signaling research.

    In stock View Details
    1 mg
    $185.00
    All 1 sizes
  • N-Lignoceroyl Taurine
    Cat. No.
    A72471
    CAS No.
    807370-75-8

    N-Lignoceroyl Taurine

    N-Lignoceroyl Taurine is an endogenous metabolite and taurine conjugate of lignoceric acid, identified through lipidomic analysis of bovine brain. This compound exhibits distinct biological activity as a substrate for fatty acid amide hydrolase (FAAH), with levels significantly elevated in FAAH knockout mice, indicating a potential role in lipid metabolism. Additionally, N-Lignoceroyl Taurine has been shown to activate transient receptor potential (TRP) calcium channels, including TRPV1 and TRPV4, highlighting its relevance in neurobiology and cellular signaling research.

    In stock View Details
    1 mg
    $145.00
    5 mg
    $665.00
    All 3 sizes
  • D-myo-Inositol-1,3,4,5-tetrakisphosphate potassium
    Cat. No.
    A90347
    CAS No.
    135269-51-1

    D-myo-Inositol-1,3,4,5-tetrakisphosphate potassium

    D-myo-Inositol-1,3,4,5-tetrakisphosphate potassium acts as a Ca2+ inducer by enhancing extracellular calcium entry via the upregulation of voltage-gated calcium channels. This compound is instrumental in studies related to calcium signaling pathways and is often utilized in investigations of cellular processes influenced by calcium ions. It serves as a valuable reagent for researchers exploring the roles of calcium in various physiological and pathological contexts.

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    Out of stock

    All 3 sizes

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