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TXA497

Local Topical Bactericide

TXA497 is a potent local topical bactericide that targets the bacterial cell division protein FtsZ, disrupting its polymerization kinetics. This compound demonstrates significant bactericidal activity against various strains of Staphylococcus aureus, including both MRSA and MSSA, with a minimum inhibitory concentration (MIC) between 1.0 and 2.0 μg/mL. TXA497 exhibits concentration-dependent skin deposition, adhering to Fick's first law, and has limited systemic permeability through the stratum corneum lipid pathway. This reagent is suitable for research focused on the development and study of topical bactericidal agents.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	1404289-52-6
Applications	Local Topical Bactericide
Formula	C₁₈H₂₃N₃
Molecular Weight	281.40
SMILES	NC(NCC1=CC(C2=CC=C(C(C)(C)C)C=C2)=CC=C1)=N

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.