UNC6934 is a potent and selective chemical probe targeting the N-terminal PWWP1 domain of NSD2 (nuclear receptor-binding SET domain protein 2). It binds NSD2-PWWP1 with a Kd of 80 nM (measured by SPR) and exhibits high selectivity over 14 other PWWP domains, including NSD3-PWWP1. In U2OS cells, UNC6934 disrupts the interaction between NSD2-PWWP1 and H3K36me2-marked nucleosomes, with an IC₅₀ of 1.09 μM as determined by NanoBRET assay. It is a valuable tool for studying NSD2 chromatin interactions and epigenetic regulation.
UNC6934 is a potent and selective chemical probe targeting the N-terminal PWWP1 domain of NSD2 (nuclear receptor-binding SET domain protein 2). It binds NSD2-PWWP1 with a Kd of 80 nM (measured by SPR) and exhibits high selectivity over 14 other PWWP domains, including NSD3-PWWP1. In U2OS cells, UNC6934 disrupts the interaction between NSD2-PWWP1 and H3K36me2-marked nucleosomes, with an IC₅₀ of 1.09 μM as determined by NanoBRET assay. It is a valuable tool for studying NSD2 chromatin interactions and epigenetic regulation.
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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