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URAT1 inhibitor 11

Catalog No.: A68909
URAT1 Inhibitor
URAT1 Inhibitor 11 is a potent inhibitor of the URAT1 transporter, exhibiting an IC50 value of 0.18 μM. This compound demonstrates significant hypouricemic effects in hyperuricemic zebrafish models induced by potassium oxonate and xanthine sodium salt. URAT1 Inhibitor 11 serves as a valuable tool for research applications focused on hyperuricemia and related metabolic disorders.
URAT1 inhibitor 11 2416416-13-0 URAT1 Inhibitor
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionURAT1 Inhibitor 11 is a potent inhibitor of the URAT1 transporter, exhibiting an IC50 value of 0.18 μM. This compound demonstrates significant hypouricemic effects in hyperuricemic zebrafish models induced by potassium oxonate and xanthine sodium salt. URAT1 Inhibitor 11 serves as a valuable tool for research applications focused on hyperuricemia and related metabolic disorders.
Product Information
Catalog NumA68909
FormulaC20H16F4N2O2
Molecular Weight392.35
CAS Number2416416-13-0
SMILESOC(CCCN(C1=CC(F)=CC=C1)C2=CC=NC3=CC=C(C(F)(F)F)C=C32)=O
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Membrane Transporters-Ion Channels > URAT1