VR23

Catalog No.: A13650

Proteasome inhibitor‎

VR23

VR23 Chemical Structure

CAS NO. 1624602-30-7

VR23 is a small molecule that potently inhibited the activities of trypsin-like proteasomes (IC50 = 1 nM), chymotrypsin-like proteasomes (IC50 = 50-100 nM), and caspase-like proteasomes (IC50 = 3uM).

Availability: In stock

Package Price Qty
5 mg
$65.00
10 mg
$110.00
25 mg
$220.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

VR23 is a small molecule that potently inhibited the activities of trypsin-like proteasomes (IC50 = 1 nM), chymotrypsin-like proteasomes (IC50 = 50-100 nM), and caspase-like proteasomes (IC50 = 3uM).
Targets
Trypsin-like proteasomes Chymotrypsin-like proteasomes Caspase-like proteasomes
1 nM50-100 nM3 μM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.93 mL 104.63 mL 209.26 mL
0.5 mM 4.19 mL 20.93 mL 41.85 mL
1 mM 2.09 mL 10.46 mL 20.93 mL
5 mM 0.42 mL 2.09 mL 4.19 mL

*The above data is based on the productmolecular weight 477.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13650
Actions Inhibitor
M. Wt 477.88
Formula C19H16ClN5O6S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1624602-30-7
Synonyms VR-23, VR 23
SMILES ClC1=CC2=C(C(N3CCN(S(C4=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C4)(=O)=O)CC3)=CC=N2)C=C1

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