VR23

Catalog No.: A13650

Proteasome inhibitor‎

VR23

VR23 Chemical Structure

CAS NO. 1624602-30-7

VR23 is a small molecule that potently inhibited the activities of trypsin-like proteasomes (IC50 = 1 nM), chymotrypsin-like proteasomes (IC50 = 50-100 nM), and caspase-like proteasomes (IC50 = 3uM).

Availability: In stock

Package Price Qty
5 mg
$65.00
10 mg
$110.00
25 mg
$220.00
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Biological Activity

VR23 is a small molecule that potently inhibited the activities of trypsin-like proteasomes (IC50 = 1 nM), chymotrypsin-like proteasomes (IC50 = 50-100 nM), and caspase-like proteasomes (IC50 = 3uM).
Targets
Trypsin-like proteasomes Chymotrypsin-like proteasomes Caspase-like proteasomes
1 nM50-100 nM3 μM
In vitro DMSO Warmed: 29 mg/mL (60.68 mM)
Water Warmed: 5 mg/mL (10.46 mM)
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.93 mL 104.63 mL 209.26 mL
0.5 mM 4.19 mL 20.93 mL 41.85 mL
1 mM 2.09 mL 10.46 mL 20.93 mL
5 mM 0.42 mL 2.09 mL 4.19 mL

*The above data is based on the productmolecular weight 477.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13650
Actions Inhibitor
CAS No. 1624602-30-7
Formula C19H16ClN5O6S
M. Wt 477.88
Purity >98%
Synonyms VR-23, VR 23
SMILES ClC1=CC2=C(C(N3CCN(S(C4=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C4)(=O)=O)CC3)=CC=N2)C=C1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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