WCK-4234 is a potent β-lactamase inhibitor that effectively targets class A, C, and D β-lactamases. While lacking direct antibacterial activity, WCK-4234 enhances the efficacy of carbapenems such as imipenem and meropenem against Enterobacteriaceae possessing OXA-48/OXA-181 or KPC enzymes, as well as those exhibiting combinations of impermeability and AmpC or ESBL activity. This compound is particularly noteworthy for its ability to overcome resistance conferred by OXA-type carbapenemases, making it valuable for research in antibiotic resistance mechanisms.
WCK-4234 is a potent β-lactamase inhibitor that effectively targets class A, C, and D β-lactamases. While lacking direct antibacterial activity, WCK-4234 enhances the efficacy of carbapenems such as imipenem and meropenem against Enterobacteriaceae possessing OXA-48/OXA-181 or KPC enzymes, as well as those exhibiting combinations of impermeability and AmpC or ESBL activity. This compound is particularly noteworthy for its ability to overcome resistance conferred by OXA-type carbapenemases, making it valuable for research in antibiotic resistance mechanisms.
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