Fig. 1 · Structure
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Wf-516
Serotonin Transporter Inhibitor
Wf-516 is a potent inhibitor of the serotonin transporter (5-HT reuptake), exhibiting a Ki of 5 nM against the 5-HT1A receptor and 40 nM against the 5-HT2A receptor in human models. This compound acts as an antagonist at these receptors, demonstrating significant antidepressant activity. Wf-516 is utilized in research focused on mood disorders and the modulation of serotonergic pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 310392-94-0 |
| Applications | Serotonin Transporter Inhibitor |
| Formula | C25H25Cl2N3O4 |
| Molecular Weight | 502.39 |
| SMILES | O[C@H](COC1=C2C=C(C3=NN=C(C)O3)OC2=CC=C1)CN(CC4)CCC4C5=CC=C(Cl)C(Cl)=C5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.