Xylitol is a polyol classified as a sugar alcohol, known for its inhibitory effects on cancer cell proliferation. It induces autophagy and promotes cell death in A549 lung cancer cells by activating the autophagy signaling pathway, as indicated by increased levels of LC3-II and Atg5-Atg12. Additionally, Xylitol reduces acetaldehyde production by Candida species, thereby mitigating their carcinogenic potential. In vivo studies demonstrate that Xylitol modifies gut microbiota in mice, potentially enhancing cholesterol accumulation, upregulating hepatic ChREBP, and inhibiting tumor growth in the B16F10 melanoma model.
Xylitol is a polyol classified as a sugar alcohol, known for its inhibitory effects on cancer cell proliferation. It induces autophagy and promotes cell death in A549 lung cancer cells by activating the autophagy signaling pathway, as indicated by increased levels of LC3-II and Atg5-Atg12. Additionally, Xylitol reduces acetaldehyde production by Candida species, thereby mitigating their carcinogenic potential. In vivo studies demonstrate that Xylitol modifies gut microbiota in mice, potentially enhancing cholesterol accumulation, upregulating hepatic ChREBP, and inhibiting tumor growth in the B16F10 melanoma model.
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