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Y08060

Catalog No.: A40593
BET Inhibitor
Y08060 is a selective inhibitor of Bromodomain and Extra-Terminal (BET) proteins. It demonstrates significant anti-proliferative effects on C4-2B and LNCaP prostate cancer cell lines, with IC50 values of 3.23 μM and 4.41 μM, respectively. Additionally, Y08060 effectively suppresses colony formation and androgen receptor (AR) expression in these cell lines, making it a valuable tool for research applications targeting prostate cancer biology.
Y08060 2222565-19-5 BET Inhibitor
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionY08060 is a selective inhibitor of Bromodomain and Extra-Terminal (BET) proteins. It demonstrates significant anti-proliferative effects on C4-2B and LNCaP prostate cancer cell lines, with IC50 values of 3.23 μM and 4.41 μM, respectively. Additionally, Y08060 effectively suppresses colony formation and androgen receptor (AR) expression in these cell lines, making it a valuable tool for research applications targeting prostate cancer biology.
Product Information
Catalog NumA40593
FormulaC18H19BrN2O6S
Molecular Weight471.32
CAS Number2222565-19-5
SMILESO=C1NC2=CC(OC)=C(NS(=O)(C3=CC(Br)=CC=C3OC)=O)C=C2OC1(C)C
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