(+)-JQ1

Catalog No.: A12729

BET Inhibitor

(+)-JQ1

(+)-JQ1 Chemical Structure

CAS NO. 1268524-70-4

(+)-JQ1 is a potent, high affinity, selective BET bromodomain inhibitor.

Availability: In stock

Package Price Qty
5 mg
$70.00
10 mg
$90.00
25 mg
$120.00
50 mg
$160.00
10mM * 1mL in DMSO
$132.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Nandini Verma, .et al. Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis, Sci Adv, 2020, 6 : eaba8968
  • Kuo MT, .et al. Collaboration Between RSK-EphA2 and Gas6-Axl RTK Signaling in Arginine Starvation Response That Confers Resistance to EGFR Inhibitors, Transl Oncol, 2020, 13(2):355-364 PMID: 31887630
  • A Carrer, .et al. Acetyl-CoA metabolism supports multi-step pancreatic tumorigenesis, Cancer Discov, 2019, Jan 9. pii: CD-18-0567 PMID: 30626590
  • Rao Z, .et al. Vacuolar (H+)-ATPase Critically Regulates Specialized Proresolving Mediator Pathways in Human M2-like Monocyte-Derived Macrophages and Has a Crucial Role in Resolution of Inflammation, J Immunol, 2019, Aug 15;203(4):1031-1043 PMID: 31300512
  • Clocchiatti A, .et al. Androgen receptor functions as transcriptional repressor of cancer-associated fibroblast activation, J Clin Invest, 2018, Dec 3;128(12):5531-5548 PMID: 30395538

Biological Activity

(+)-JQ1 is a potent, high affinity, selective BET bromodomain inhibitor.
In vitro (25°C) DMSO Warmed: 90 mg/mL (196.93 mM)
Water Insoluble
Ethanol 90 mg/mL
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.88 mL 109.41 mL 218.82 mL
0.5 mM 4.38 mL 21.88 mL 43.76 mL
1 mM 2.19 mL 10.94 mL 21.88 mL
5 mM 0.44 mL 2.19 mL 4.38 mL

*The above data is based on the productmolecular weight 456.99. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12729
Actions Inhibitor
CAS No. 1268524-70-4
Formula C23H25ClN4O2S
M. Wt 456.99
Purity >98%
SMILES CC1=C(SC2=C1C(=N[[email protected]](C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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