(+)-JQ1

Catalog No.: A12729
BET Inhibitor
(+)-JQ1 is a potent, high affinity, selective BET bromodomain inhibitor.
Grouped product items
Product Name Price Stock Qty
(+)-JQ1 5mg
$50.00
In stock
(+)-JQ1 10mg
$70.00
In stock
(+)-JQ1 25mg
$110.00
In stock
(+)-JQ1 50mg
$150.00
In stock
(+)-JQ1 10mM * 1mL in DMSO
$60.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's (+)-JQ1 has been cited by 10 publications
  • Adriana K Alexander, .et al. , Nat Commun, 2023, Mar 29;14(1):1753 PMID: 36990976
  • Haruki Kitamura, .et al. , Biochem Biophys Res Commun, 2023, Jan 22;641:139-147 PMID: 36527748
  • Gerald Thiel, .et al. , Pharmaceuticals (Basel), 2022, Jul 10;15(7):846 PMID: 35890145
  • Selase D Deletsu, .et al. , Biochem Biophys Res Commun, 2021, Aug 27;567:106-111 PMID: 34146904
  • Cole Schonhofer, .et al. , Biochem Pharmacol, 2021, Apr;186:114462 PMID: 33577894
  • Nandini Verma, .et al. , Sci Adv, 2020, 6 : eaba8968
  • Kuo MT, .et al. , Transl Oncol, 2020, 13(2):355-364 PMID: 31887630
  • Rao Z, .et al. , J Immunol, 2019, Aug 15;203(4):1031-1043 PMID: 31300512
  • A Carrer, .et al. , Cancer Discov, 2019, Jan 9. pii: CD-18-0567 PMID: 30626590
  • Clocchiatti A, .et al. , J Clin Invest, 2018, Dec 3;128(12):5531-5548 PMID: 30395538
  • Biological Activity
    Discription (+)-JQ1 is a potent, high affinity, selective BET bromodomain inhibitor.
    Product Information
    Catalog Num A12729
    Formula C23H25ClN4O2S
    Molecular Weight 456.99
    CAS Number 1268524-70-4
    SMILES CC1=C(SC2=C1C(=N[C@H](C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO Warmed: 90 mg/mL (196.93 mM)
    Water Insoluble
    Ethanol 90 mg/mL
    In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 4 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 21.88 mL 109.41 mL 218.82 mL
    0.5 mM 4.38 mL 21.88 mL 43.76 mL
    1 mM 2.19 mL 10.94 mL 21.88 mL
    5 mM 0.44 mL 2.19 mL 4.38 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

    • Mass

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      Molecular Weight

    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

    • C1

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