Fig. 1 · Structure
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YF-2 hydrochloride
Histone Acetyltransferase Activator
YF-2 hydrochloride is a selective histone acetyltransferase activator targeting CBP, PCAF, and GCN5 with EC50 values of 2.75 μM, 29.04 μM, and 49.31 μM, respectively, while demonstrating no inhibitory effects on HDAC. This compound effectively acetylates histone H3 in the hippocampus and is capable of crossing the blood-brain barrier. YF-2 hydrochloride is primarily utilized in research focused on cancer biology and neurodegenerative diseases, including Alzheimer's disease.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 1312005-62-1 |
| Applications | Histone Acetyltransferase Activator |
| Formula | C20H23Cl2F3N2O3 |
| Molecular Weight | 467.31 |
| SMILES | O=C(NC1=CC=C(Cl)C(C(F)(F)F)=C1)C2=C(OCC)C=CC=C2OCCN(C)C.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.