AG-1024 (Tyrphostin)

AG-1024 (Tyrphostin) is a specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kinase activity. Exhibits lower IC50 values for IGF-1 than for the insulin receptor. Also inhibits insulin-stimulated cellular proliferation.
Grouped product items
Size Price Stock Qty
2mg
$25.00
In stock
5mg
$45.00
In stock
10mg
$80.00
In stock
25mg
$150.00
In stock
50mg
$235.00
In stock
100mg
$365.00
In stock
10mM * 1mL in DMSO
$50.00
In stock
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Adooq's AG-1024 (Tyrphostin) has been cited by 1 publications
Biological Activity
DescriptionAG-1024 (Tyrphostin) is a specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kinase activity. Exhibits lower IC50 values for IGF-1 than for the insulin receptor. Also inhibits insulin-stimulated cellular proliferation.
Targets
TargetValue
Product Information
Catalog NumA11400
FormulaC14H13BrN2O
Molecular Weight305.2
CAS Number65678-07-1
SMILESCC(C)(C)C1=C(C(=CC(=C1)C=C(C#N)C#N)Br)O
SynonymsAG1024
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO59 mg/mL (193.33 mM)
WaterInsoluble
EthanolInsoluble
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM32.77 mL163.83 mL327.65 mL
0.5 mM6.55 mL32.77 mL65.53 mL
1 mM3.28 mL16.38 mL32.77 mL
5 mM0.66 mL3.28 mL6.55 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Calculate the dilution required to prepare a stock solution.
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