BMS-754807

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IGF-1R inhibitor

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Catalog No. A11059

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
BMS-754807 5mg A11059-5
$60.00
BMS-754807 10mg A11059-10
$100.00
BMS-754807 50mg A11059-50
$350.00
BMS-754807 100mg A11059-100
$600.00
BMS-754807 10mM * 1mL in DMSO A11059-10mM-D
$65.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

BMS-754807 is an efficacious, orally active growth factor 1 receptor/insulin receptor family-targeted kinase inhibitor that may act in combination with a wide array of established anticancer agents.

BMS-754807

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Chemical Information

Catalog Num A11059
Actions Inhibitor
M. Wt 461.5
Formula C23H24FN9O
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1001350-96-4
Synonyms BMS754807, BMS 754807
SMILES code C[C@]1(CCCN1C2=NN3C=CC=C3C(=N2)NC4=NNC(=C4)C5CC5)C(=O)NC6=CN=C(C=C6)F
Chemical Name (2S)-1-[4-[(5-Cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]-N-(6-fluoro-3-pyridinyl)-2-methyl-2-pyrrolidinecarboxamide

Biological Activity

Description
BMS-754807 is an efficacious, orally active growth factor 1 receptor/insulin receptor family-targeted kinase inhibitor that may act in combination with a wide array of established anticancer agents.
Targets
Target Value
Insulin ReceptorIC50: 1.7nM
IGF-1RIC50: 1.8nM
TrkBIC50: 4.1nM
MetIC50: 5.6nM
TrkAIC50: 7.4nM
AuroraAIC50: 9nM
AuroraBIC50: 25nM
RONIC50: 44nM
FLT3IC50: 170nM
JAK2IC50: 347nM
GSK-3βIC50: 785nM
CDK2EIC50: 795nM
MK2IC50: 919nM
LCKIC50: 1.218μM
SrcIC50: 1.527μM
PKAIC50: 1.605μM
PKCαIC50: 2.53μM
BTKIC50: 3.797μM
CSKIC50: 5μM
PKCδIC50: 12μM
PKCζIC50: >50μM
PKCιIC50: >50μM
p38αIC50: >50μM
p38βIC50: >50μM
HER1IC50: >50μM
IKK1IC50: >50μM
IKK2IC50: >50μM

Solubility

Solubility (25°C) * In vitro DMSO 92 mg/mL (199.35 mM)
Water <1 mg/mL (<1 mM)
Ethanol 92 mg/mL (199.35 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 20 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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