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EGFR/HER2

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  • AEE788

    A10043 AEE788

    AEE788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor that inhibits phosphorylation of the tyrosine kinases of EGFR, HER2 and VEGF2.
  • AG-1478 (Tyrphostin AG-1478)

    A11022 AG-1478 (Tyrphostin AG-1478)

    AG-1478 (Tyrphostin AG-1478) is an inhibitor of EGFR kinase with an IC50 value of 3 nM.
  • AG-17

    A11949 AG-17

    AG-17 is an inhibitor of EGF receptor kinase with an IC50 value of 460 µM in the human epidermoid carcinoma cell line A431.
  • AG-490

    A10047 AG-490

    AG 490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively).
  • Arry-380

    A11027 Arry-380

    ARRY-380 is an ErbB-2 inhibitor that selectively binds to and inhibits the phosphorylation of ErbB-2, resulting in growth inhibition and death of ErbB-2-expressing tumor cells.
  • ARRY334543

    A11158 ARRY334543

    ARRY334543 is a potent, orally active small molecule inhibitor of EGFR and ErbB-2.
  • AST-1306

    A11155 AST-1306

    AST-1306, a novel anilino-quinazoline compound, inhibits the enzymatic activities of wild-type epidermal growth factor receptor (EGFR) and ErbB2 as well as EGFR resistant mutant in both cell-free and cell-based systems.
  • AST-6

    A10062 AST-6

    AST-6 is a novel irreversible inhibitor of the epidermal growth factor receptor 1 and 2, inhibits tumor growth both in vitro and in vivo
  • AV-412

    A11028 AV-412

    AV-412 is an EGFR/HER2 inhibitor that binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may result in the inhibition of tumor growth and angiogenesis.
  • AZD8931

    A10116 AZD8931

    AZD8931 is an oral, equipotent inhibitor of ErbB1, ErbB2 and ErbB3 receptor signaling.
  • BIBW2992 (Afatinib)

    A10141 BIBW2992 (Afatinib)

    BIBW2992 (Afatinib) is tyrosine kinase inhibitor (TKI) that irreversibly inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases.
  • BIBX 1382

    A11334 BIBX 1382

    BIBX 1382 is a cell-permeable pyrimidopyrimidine compound that acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of EGFR.
  • BMS 599626 (AC480)

    A11209 BMS 599626 (AC480)

    BMS 599626 is an orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases (IC50=22, 32 and 190 nM, respectively) with potential antineoplastic activity.
  • Canertinib (CI-1033)

    A10211 Canertinib (CI-1033)

    Canertinib (CI-1033) is an irreversible tyrosine-kinase inhibitor with activity against EGFR (IC50 0.8 nM), HER-2 (IC50 19 nM) and ErbB-4 (IC50 7 nM).
  • Chrysophanic acid (Chrysophanol)

    A10210 Chrysophanic acid (Chrysophanol)

    Chrysophanic acid (Chrysophanol) blocks proliferation of colon cancer cells by inhibiting EGFR/mTOR pathway.
  • CP-724714

    A10242 CP-724714

    CP-724714 is an orally available, small molecule, potent HER-2 tyrosine kinase inhibitor that inhibits HER2 kinase (IC50 3.8 ng/ml) .
  • Erlotinib Hydrochloride

    A10362 Erlotinib Hydrochloride

    Erlotinib hydrochloride is a reversible tyrosine kinase inhibitor, which acts on the epidermal growth factor receptor (EGFR).
  • Gefitinib (Iressa)

    A10422 Gefitinib (Iressa)

    Gefitinib is an EGFR inhibitor, which interrupts signaling through the epidermal growth factor receptor (EGFR) in target cells.
  • Lapatinib (free base)

    A11752 Lapatinib (free base)

    Lapatinib is a dual tyrosine kinase inhibitor which interrupts the HER2 growth receptor pathway.
  • Lapatinib Ditosylate

    A10514 Lapatinib Ditosylate

    Lapatinib is a dual tyrosine kinase inhibitor which interrupts the HER2 growth receptor pathway.
  • Mubritinib (TAK 165)

    A10612 Mubritinib (TAK 165)

    Mubritinib (TAK 165) is a potent EGFR and p34cdc2 inhibitor with IC50 of 6 nM and 0.2 µM, respectively. Mubritinib(TAK 165) also inhibits p33cdk2 and p33cdk5.
  • Neratinib (HKI-272)

    A10638 Neratinib (HKI-272)

    Neratinib (HKI-272) is a tyrosine kinase inhibitor.
  • OSI-420

    A10678 OSI-420

    OSI-420 (Desmethyl Erlotinib,CP-473420) is an orally active EGFR tyrosin kinase inhibitor, which inhibits receptor tyrosine kinases (TKs) by inhibition of the intercellular domain .
  • PD153035 (HCl salt)

    A10702 PD153035 (HCl salt)

    PD153035 is an extremely potent and specific inhibitor of the tyrosine kinase activity of EGFR.
  • Pelitinib (EKB-569)

    A10706 Pelitinib (EKB-569)

    Pelitinib (EKB-569) is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity.
  • PF299804

    A11051 PF299804

    PF299804 is a potent, orally available, irreversible inhibitor of tyrosine kinase human epidermal growth factor receptors (HER) 1 (EGFR), HER2, and HER4.
  • TAK-285

    A11236 TAK-285

    TAK-285 is an investigational HER2/EGFR inhibitor that penetrates the CNS in Rats with an Intact Blood Brain Barrier (BBB).
  • Tyrphostin AG 879

    A10053 Tyrphostin AG 879

    Tyrphostin AG 879 is an inhibitor of the tyrosine kinase activity of nerve growth factor (NGF) TrkA.
  • WZ3146

    A10990 WZ3146

    WZ3146 is an inhibitor of EGFR receptor kinase mutants carrying a mutation in an active site gatekeeper residue (T790M) and is much less potent against wild-type EGFR kinase.
  • WZ4002

    A10991 WZ4002

    WZ4002 is EGFR inhibitor against EGFR T790M (mutation of the gatekeeper T790 residue) which is detected in 50% of clinically resistant patients to gefitinib or erlotinib.
  • WZ8040

    A10992 WZ8040

    WZ8040 is a novel EGFR inhibitors that suppress the growth of EGFR-T790M-containing cell lines and inhibit EGFR phosphorylation.
  • XL647

    A11057 XL647

    XL647 is an orally bioavailable small-molecule RTK inhibitor that binds to and inhibits several tyrosine receptor kinases that play major roles in tumor cell proliferation and tumor vascularization, including EGFR, HER2, ERBB2, VEGFR and EphB4.

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