Mubritinib (TAK 165)

Catalog No.: A10612

HER2/ErbB2 inhibitor

Mubritinib (TAK 165)

Mubritinib (TAK 165) Chemical Structure

CAS NO. 366017-09-6

Mubritinib (TAK 165) is a potent EGFR and p34cdc2 inhibitor with IC50 of 6 nM and 0.2 µM, respectively. Mubritinib(TAK 165) also inhibits p33cdk2 and p33cdk5.

Availability: In stock

Package Price Qty
10 mg
$40.00
25 mg
$100.00
50 mg
$180.00
200 mg
$580.00
10mM * 1mL in DMSO
$50.00
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Biological Activity

Mubritinib (TAK 165) is a potent EGFR and p34cdc2 inhibitor with IC50 of 6 nM and 0.2 µM, respectively. Mubritinib(TAK 165) also inhibits p33cdk2 and p33cdk5.
Targets
Target Value
HER2/ErbB2IC50: 6.0nM
EGFRIC50: >25μM
FGFRIC50: >25μM
PDGFRIC50: >25μM
JAK1IC50: >25μM
SrcIC50: >25μM
BLKIC50: >25μM
In vitro (25°C) DMSO 13 mg/mL (27.74 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.34 mL 106.72 mL 213.45 mL
0.5 mM 4.27 mL 21.34 mL 42.69 mL
1 mM 2.13 mL 10.67 mL 21.34 mL
5 mM 0.43 mL 2.13 mL 4.27 mL

*The above data is based on the productmolecular weight 468.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10612
Actions Inhibitor
M. Wt 468.5
Formula C25H23F3N4O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 366017-09-6
Synonyms TAK-165, TAK165
SMILES C1=CC(=CC=C1CCCCN2C=CN=N2)OCC3=COC(=N3)/C=C/C4=CC=C(C=C4)C(F)(F)F

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