EGFR/HER2

Cat. No.

A18337

CAS No.

133550-34-2

AG 555

Synonyms: Tyrphostin AG 555

AG555 is a potent epidermal growth factor receptor (EGFR) kinase inhibitor.

Cat. No.

A18562

CAS No.

2267329-76-8

TQB3804 (EGFR-IN-7)

Synonyms: EGFR-IN-7

EGFR-IN-7 (compound 34) is a selective and potent EGFR kinase inhibitor extracted from patent WO2019015655A1, has IC50s of 7.92 nM and 0.218 nM for EGFR (WT) and EGFR (mutant C797S/T790M/L858R) respectively, and shows anti-tumor activity.

Cat. No.

A18565

CAS No.

2050906-97-1

Mutated EGFR-IN-2

Mutated EGFR-IN-2 (compound 91) is a mutant-selective EGFR inhibitor extracted from patent WO2017036263A1, which potently inhibits single-mutant EGFR (T790M) and double-mutant EGFR (including L858R/T790M (IC50 ≤ 1 nM) and ex19del/T790M), and can suppress activity of single gain-of-function mutant EGFR (including L858R and ex19del) as well. Mutated EGFR-IN-2 shows anti-tumor antivity.

Cat. No.

A18857

CAS No.

1226549-49-0

DBPR112

DBPR112 is an orally active Furanopyrimidine-Based Epidermal Growth Factor Receptor inhibitor with IC50s of 15 nM and 48 nM for EGFRWT and EGFRL858R/T790M, respectively.

Cat. No.

A19067

CAS No.

1423077-49-9

RTC-5

RTC-5 is an optimized phenothiazine with anti-cancer potency. RTC-5 demonstrates efficacy against a xenograft model of an EGFR driven cancer, its effects is attributed to concomitant negative regulation of PI3K-AKT and RAS-ERK signaling.

Cat. No.

A19382

CAS No.

2088323-16-2

TAS0728

TAS0728 is a potent, selective, oral active, irreversible and covalent-binding HER2 inhibitor, binds to HER2 at C805, inhibits its kinase activity, with an IC50 of 13 nM.

Cat. No.

A19410

CAS No.

150779-71-8

SDZ281-977

Synonyms: SDZ-LAP 977

SDZ281-977 is an antiproliferative agent. It acts by binding to the “colchicine binding site” on tubulin and inhibiting tubulin polymerization in vitro.

Cat. No.

A19423

CAS No.

1269662-73-8

Pyrotinib

Synonyms: SHR-1258

Pyrotinib (SHR-1258) is a potent and selective EGFR/HER2 dual inhibitor with IC50s of 13 and 38 nM, respectively.

Cat. No.

A19541

CAS No.

1661854-97-2

Zipalertinib (TAS6417)

Synonyms: TAS 6417

TAS6417 is an EGFR inhibitor and an efficacious drug candidate for patients with NSCLC, with IC50 values ranging from 1.1-8.0 nM.

Cat. No.

A20082

CAS No.

2225887-26-1

EGFR-IN-5

EGFR-IN-5 is a EGFR inhibitor with IC50s of 10.4, 1.1, 34, 7.2 nM for EGFR, EGFRL858R, EGFRL858R/T790M, and EGFRL858R/T790M/C797S, respectively.

Cat. No.

A20455

CAS No.

136831-48-6

RG13022

Synonyms: Tyrphostin RG13022

RG13022 is a tyrosine kinase inhibitor; inhibits the autophosphorylation reaction of the EGF receptor with an IC50 of 4 μM.

Cat. No.

A20555

CAS No.

1421372-66-8

Mutated EGFR-IN-1 (Osimertinib analog)

Synonyms: Osimertinib analog

Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant.

Cat. No.

A20608

CAS No.

1428774-45-1

PF-06459988

PF-06459988 is an irreversible inhibitor of T790M-Containing EGFR Mutants.

Cat. No.

A20643

CAS No.

936446-61-6

NRC-2694

NRC-2694 is an epidermal growth factor receptor (EGFR) antagonist with anti-cancer and anti-proliferative properties.

Cat. No.

A20762

CAS No.

1448237-05-5

Naquotinib mesylate

Synonyms: ASP8273 (mesylate); ASP 8273

Naquotinib mesylate (ASP8273 mesylate) is an orally available, mutant-selective and irreversible EGFR inhibitor; with IC50s of 8-33 nM toward EGFR mutants and 230 nM for EGFR.

Cat. No.

A20849

CAS No.

1636180-98-7

Tarloxotinib bromide

Synonyms: TH-4000

Tarloxotinib bromide (TH-4000) is an irreversible EGFR/HER2 inhibitor.

Cat. No.

A20988

CAS No.

1446090-77-2

rel-Lifirafenib

Synonyms: BGB-283

Lifirafenib (BGB-283) is a novel and potent Raf Kinase and EGFR inhibitor with IC50 values of 23 and 29 nM for recombinant BRafV600E and EGFR, respectively.

Cat. No.

A21144

CAS No.

1421373-62-7

Mutant EGFR inhibitor

Mutant EGFR inhibitor is a potent and selective mutant EGFR inhibitor extracted from patent WO 2013014448 A1; inhibits EGFRL858R, EGFRExon 19 deletion and EGFRT790M.

Cat. No.

A21288

CAS No.

807640-87-5

BGB-102

Synonyms: JNJ-26483327

BGB-102 is a potent multi-kinase inhibitor against EGFR, HER2, and HER4 with IC50s of 9.6 nM, 18 nM and 40.3 nM, respectively.

Cat. No.

A21661

CAS No.

2134096-03-8

Almonertinib hydrochloride (HS-10296)

Synonyms: HS10296

HS-10296 hydrochloride is an orally available and third-Generation inhibitor of epidermal growth factor receptor (EGFR)-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR.

Cat. No.

A21664

CAS No.

714971-09-2

BMS-599626

Synonyms: AC480

BMS-599626 (AC480) is a selective and orally bioavailable HER1 and HER2 inhibitor, with IC50s of 20 and 30 nM, respectively.

Cat. No.

A21666

CAS No.

2130958-55-1

Firmonertinib (AST2818) mesylate

Synonyms: AST 2818

AST2818 mesylate is an EGFR inhibitor.

Cat. No.

A21741

CAS No.

1508250-72-3

Nazartinib mesylate

Synonyms: EGF816 (mesylate); EGF 816

Nazartinib mesylate (EGF816 mesylate) is a novel, covalent mutant-selective EGFR inhibitor, with Ki and Kinact of 31 nM and 0.222 min?1 on EGFR(L858R/790M) mutant, respectively.

Cat. No.

A21747

CAS No.

1508256-20-9

Nazartinib S-enantiomer

Synonyms: EGF816 (S-enantiomer); EGF 816

Nazartinib S-enantiomer (EGF816 S-enantiomer) is the less active S-enantiomer of Nazartinib. Nazartinib (EGF816) is an EGFR inhibitor.

Cat. No.

A21756

CAS No.

1397922-61-0

Pyrotinib dimaleate

Synonyms: SHR-1258 dimaleate; SHR1258

Pyrotinib dimaleate (SHR-1258 dimaleate) is a potent and selective EGFR/HER2 dual inhibitor with IC50 s of 13 and 38 nM, respectively.